Study design

Method comparison study requirements and dataset layout.

Requirements

  • 2 quantitative variables.
  • A recommended minimum of at least 40 cases.
  • Each measurement in singlicate or replicate.

Paired dataset layout

Use a column for each method (Method 1, Method 2); each row has the measurement by each method for an item (Subject).

Subject (optional) Method 1 Method 2
1 120 121
2 113 118
3 167 150
4 185 181
5 122 122

Paired dataset layout with replicates

Use multiple columns for the replicates of each method (Method 1, Method 2); each row has the replicate measurements by each method for an item (Subject).

Subject (optional) Method 1 Method 2
1 120 122 121 120
2 113 110 118 119
3 167 170 150 155
4 185 188 181 180
5 122 123 122 130

Paired dataset layout with matched replicates

Use a column for each method (Method 1, Method 2); each row has the measurements by each methods for an item (Subject), with multiple rows for replicates of each item.

Subject Method 1 Method 2
1 120 121
1 122 120
2 113 118
2 110 119
3 167 150
3 170 155
4 185 181
4 188 180
5 122 122
5 123 130

Matched dataset layout

Use a column for the measurement variable (Measured value), a column for the method variable (Method), and a column for the item variable (Subject); each row has the measurement for a method for an item (Subject), with multiple rows for replicates of each item.

Subject Method Measured value
1 X 120
1 X 122
1 Y 121
1 Y 120
2 X 113
2 X 110
2 Y 118
2 Y 119
3 X 167
3 X 170
3 Y 150
3 Y 155
4 X 185
4 X 188
4 Y 181
4 Y 180
5 X 122
5 X 123
5 Y 122
5 Y 130