Reference Range / Reference Interval Software Define, establish, and verify reference intervals in line with CLSI EP28‑A3C — directly in Excel.

Trusted by over 60,000 users at top-10 IVD manufacturers for more than 30 years.

Accurate, compliant reference intervals
Apply CLSI EP28‑A3C guidance to ensure your intervals meet regulatory and clinical expectations.
Establish intervals for healthy populations
Use parametric, non‑parametric, robust, bootstrap, and Harrell‑Davis quantile methods to derive reliable limits for any distribution.
Partition by clinically relevant factors
Create separate intervals for sex, age, ethnicity, or any number of subgroups to reflect true biological differences.
Apply transformations for non‑normal data
Use log, square‑root, Box‑Cox, Manly, or 2‑stage exponential/modulus to transform data to meet normality assumptions
Verify or transfer existing intervals
Confirm whether published or manufacturer‑provided intervals are transferable between laboratories or measurement procedures.
Runs in Microsoft Excel for easy deployment across your team. Analyse‑it integrates directly into Excel, letting you import data from instruments, analyse immediately, and generate publication‑ready reports without learning new software or managing proprietary file formats — significantly faster and more flexible than standalone tools.

We use Analyse-it frequently for our verification and pre-verification work, in accordance with CLSI guidelines for in-vitro diagnostics. It's saved time and effort compared to the hodge-podge of applications we used before, JMP, SAS, etc...

Brian Noland, Ph.D.

Principle Scientist, Product Development

Biosite / Inverness Medical Innovations
We use Analyse-it for the analysis of data necessary to file 510k. We chose Analyse-it because it works in Excel, includes CLSI protocols, and, unlike EP-Evaluator, lets us analyze data directly from equipment without typing.

Thomas D Harrigan, Ph.D.

Technical Product Manager

Alfa Wassermann Diagnostic Technologies
I used Analyse-It for many product development, product troubleshooting, and technology evaluation activities... your product was the easiest to use, was accurate, and produced publication ready reports.

Stanley F. Cernosek, Ph.D.

Clinical Chemistry Reagent Development

Beckman Coulter, Inc.
Analyse-it has been a tremendous help. I've published and presented at national cardiology meetings and couldn't have accomplished most of my research without it. Using Analyse-it, I even found errors or omissions in the work of our statistician!

Regina S. Druz, MD, FACC, FASNC

Director, Nuclear Cardiology

North Shore University Hospital
Although we only scratch the surface of Analyse-it’s capabilities, we have a very high volume of use for the statistics we need. It’s saved us time and the reports look professional.

Michael Savage

Chemistry Supervisor

Baptist Hospital East

* Available in the Analyse‑it Medical, Method Validation and Ultimate editions.

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