We are receiving a lot of questions about relevant analyses in the Analyse-it Method Validation edition to help in evaluating new diagnostic tests in the fight against COVID-19. Below are some quick links that will help, but contact us if you have questions - we are working as normal.

Also see our latest blog post: Sensitivity/Specificity and The Importance of Predictive Values for a COVID-19 test

Release version 3.52

Released 2-Oct-2013
Version 3.52
Dual 32/64-bit installer (11.37 MB)
System requirements
  • Excel 2007, 2010, 2013 (32 & 64-bit)
  • Windows Vista, 7, 8, 10, & Server 2003, 2008, 2012, 2016

Alternative download formats
.ZIP .MSI for Excel 32-bit .MSI for Excel 64-bit

 Installation instructions
 Concurrent-user installation instructions

Changes, bug fixes & improvements in this release:

Major new release of the Analyse-it Method Validation edition.

Method Comparison

  • Method comparison functions: scatters plots, difference plots, and fits, are now in one place so it’s easy to make decisions or choose fits after looking at the data.
  • Ordinary linear, Weighted linear, Ordinary Deming, Weighted Deming and Passing & Bablok regressions.
  • Constant difference and relative difference plots with mean difference, allowable difference, and limits of agreement.
  • Bootstrap confidence intervals for parameters and bias in Passing & Bablok regression.
  • Exact p-values on CUSUM linearity test.
  • Predict mean difference at decision levels.
  • Equality and equivalence hypothesis tests at decision levels.
  • Kappa and Weighted Kappa qualitative method comparison.


  • Graybill-Wang / Ting-Burdick-Graybill-Jeyaratnam-Lu modified large sample confidence interval estimators for variance components – produces confidence closer to the stated level than Satterthwaite confidence intervals, which can be too liberal.
  • Support for unbalanced 1- and 2-factor nested random ANOVA models, for looking at precision between days, runs, laboratories, etc.


  • Hsieh-Liu confidence interval estimator for degree of nonlinearity.
  • Equality and equivalence hypothesis tests for nonlinearity.

Reference interval

  • Harrell-Davis, Bootstrap, and Robust Bi-weight quantiles.
  • Box-Cox and other transformations.

Diagnostic performance / ROC

  • Compare up to 10 independent or correlated ROC curves.
  • Equality, equivalence and non-inferiority hypothesis tests.
  • Estimate false positive fraction (FPF) at fixed sensitivity, sensitivity at fixed FPF, and sensitivity/FPF at fixed cut-off.
  • Find optimal decision threshold based on costs.

Binary diagnostic tests

  • Compare sensitivity and specificity of 2 independent or correlated tests.
  • Diagnostic odds-ratio and Youden’s index.
  • Improved confidence interval estimators for likelihood ratio and predictive values.

See full release history

MSA (Measurement System Analysis) software Measurement System Analysis software Reference interval software ROC curve software Sensitivity & Specificity analysis software Method comparison software Bland-Altman software Deming regression software Passing Bablok software Method Validation software Statistical Process Control (SPC) statistical software SPC software Six Sigma statistical software Excel SPC addin Excel Statistical Process Control (SPC) add-in Pareto plot software software for Excel Pareto plot add-in software for Excel Pareto chart add-in software for Excel Control chart Excel add-in Process Capability statistical software Capability Analysis add-in software Principal Component analysis addin software Excel PCA add-in Excel ANOVA add-in ANCOVA software Multiple Regression analysis add-in software Multiple Linear Regression statistical software Excel model fitting software Excel statistics analysis addin software Excel statistical analysis addin software Statistics software Statistical analysis software
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