2020 |
Version 5.68
(3 Dec 2020)
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Minor bug fixes |
Version 5.66
(17 Aug 2020)
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Minor bug fixes |
Version 5.65
(14 Aug 2020)
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Fit model - Probit/Logit regression inverse prediction confidence intervals
Diagnostic performance - Noninferiority/Equivalence tests for comparing sensitivity/specificity
- Updated help topics for comparing sensitivity/specificity
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Version 5.61
(3 May 2020)
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Change to free trial |
Version 5.60
(27 Apr 2020)
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Fit model - Probit regression multiple inverse predictions
Method Comparison - Bangdiwala's agreement plot for visualizing agreement (Agreement plot)
- Dice-Sørensen average agreement measure
- New help topics on binary/semi-quantitative agreement measures
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Version 5.51
(2 Apr 2020)
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Fit model - Probit regression (including features to perform CLSI EP17-A2 using Probit regression) (Fitting a simple probit regression, Estimating the detection limit using a probit fit)
- Transform X and Y variable in simple regression
Distribution MSA - Predict variance at a given U for precision profile variance function
- Improved handling of small negative numbers in fitting a precision profile variance function (thanks to Bill Sadler for his suggestions)
- Hide excluded outliers in Variability plot
Method Comparison - Set seed in P&B bootstrap procedure
- Log X-axis scale on difference plots
Reference Interval - Set seed in bootstrap procedures
Diagnostic test - Multiple prior probabilities for computation of predictive values.
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2019 |
Version 5.40
(2 Oct 2019)
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Distribution / Compare groups / Compare pairs - Added TOST (two-one-sided t-test) for equivalence
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Version 5.30
(3 Jul 2019)
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Fit Model - Added Durbin-Watson test for autocorrelation
- Added weighted regression with user provided weights
Fixes for international formatting issue Distribution - Added Median Absolute Difference (MAD) to descriptive statistics
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Version 5.20
(6 Mar 2019)
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New feature: ability to specify minimum, maximum and units for a variable to help scaling chart axes. |
Version 5.11
(12 Feb 2019)
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MSA - Changed Detection Limit non-parametric quantile computation method to align with CLSI EP17
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2018 |
Version 5.10
(11 Oct 2018)
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Minor bug fixes |
Version 5.01
(10 Aug 2018)
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Added EP06-A tutorial Linearity - Weighted regression fit for scenarios where the precision is not constant across the measuring interval
- Adjust the measuring interval to find the linear range
Precision - Removed rounding of Satterthwaite DF for better compatibility with other software and EP05-A3 examples
- Fixed computation of confidence interval on partial sum of variance components
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Version 4.97
(16 Jul 2018)
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Improved quick-start guide Included example datasets and analyses Fixes for Office 2016 monitor DPI awareness |
Version 4.96
(12 Jun 2018)
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Temporarily fixes a problem where the Analyse-it user interface does not appear in the task pane on Excel 2016. A permanent fix will be available as soon as possible. |
Version 4.95
(23 May 2018)
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Improvements to the Ultimate & Method Validation editions: Added EP05-A3 tutorial MSA - Added Generalized ESD outlier identification (Grubb’s test for more than one outlier) to MSA precision analysis.
- Improved Variability plot to show possible and excluded outliers.
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2017 |
Version 4.92
(7 Dec 2017)
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Added EP15-A3 tutorial Method comparison - Various improvements to prediction interval in Deming regression
Fixed start-up issue experienced by some customers |
Version 4.91
(3 Nov 2017)
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Precision - Added 4-parameter flexible variance function for precision profiles with a turning point near the detection limit
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Version 4.90
(18 Sep 2017)
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First official release using Microsoft .NET 4 Shows active AutoFilter conditions in report header Method comparison - Added to restrict fit to a group
- Added prediction intervals to Ordinary Deming and Weighted Deming regression for commutability studies
Precision - Reorganized precision report so it's more compact by integrating additional summary table into Abbreviated and Detailed component tables
- Fixed bug in precision profile where the variance function fit could result in negative variance estimates due to a flaw in detecting boundary condition (thanks to Bill Sadler for raising this issue)
- Added constraints for J parameter in 3-parameter variance function
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Version 4.81
(27 Jun 2017)
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Round-up of recent minor fixes Method comparison - Fix for Mean vs 1st replicate computing lambda for Deming regression with unequal replicates per item.
Initial test release for .NET 4.0 |
Version 4.80
(30 Mar 2017)
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ANOVA / ANCOVA added - Fit model now supports ANOVA and ANCOVA models (2-way, 3-way and more).
- Main effect and interaction plots.
- Multiple comparisons of means.
Cronbach’s alpha Save analysis options as default on Descriptive tasks Major improvements to help system - Added many common tasks
- Included dataset layout for each type of analysis
Code signed assemblies |
2016 |
Version 4.65
(4 Oct 2016)
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Analyse-it Method Validation edition, version 4.65 Method comparison - Added vary color / symbol by to plots allowing identification of stratification
- Added mean of X vs 1st Y replicate for compatibility with version 2
- Added Sy.x to Deming regression for compatibility with version 2
MSA - Changed colors on variability plot to be more distinctive
Fit Model - Changed vary color / symbol by to apply to residual and other diagnostic plots in addition to the scatter plot
Fix to linearity scatter plot |
Version 4.60
(28 Apr 2016)
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Analyse-it Method Validation edition, version 4.60 MSA Precision analysis - Added support for 3 nested factors, for CLSI EP05-A3 multi-laboratory studies
Fix to print area for international users Fix for MSA variability plot showing blank with only replicates Minor fixes and improvements. |
2015 |
Version 4.51
(15 Dec 2015)
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Release candidate of the Analyse-it Quality Control and Improvement edition, see http://analyse-it.com/blog/2015/10/announcing-the-analyse-it-quality-control-improvement-edition Reference Interval & Diagnostic performance - Combined onto a single menu
MSA - Added tool-tips
- Fixed assigned values sometimes could not be assigned to levels on MSA
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Version 4.20
(28 Sep 2015)
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Initial support for Excel 2016 |
Version 4.10
(2 Sep 2015)
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Improved performance and reduced memory requirements for Passing-Bablok bootstrapped confidence intervals |
Version 4.00
(7 Jul 2015)
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Analyse-it Method Validation edition, version 4.00 - Support for CLSI guidelines
Reference interval - Partition factors for separate reference interval analysis of sub-groups.
- Additional transformation functions: Manly exponential, 2-stage Exponential/Modulus transformation.
- Normal MVUE quantile estimator for reference limits.
Diagnostic performance - Bi-Histogram and dot-pot of the distribution of positive/negative cases.
Method comparison - Adjust measuring interval to a linear range and extrapolate fits beyond the data to the measuring interval.
- Partition into measuring intervals, with different relationships (e.g. constant / relative differences or variances) for each measuring interval.
Linearity - Improved report and plots.
- Integrated into MSA to allow unified approach to evaluation of other components of error.
Precision - Improved report and plots.
- Precision profile variance function fits with a choice of 7 fits, including Sadler 3-parameter functions.
- Limit of quantitation via prediction from CV% on precision profile plot.
Trueness (NEW!) - Estimate bias with reference materials or PT/EQA material.
Detection capability (NEW!) - Estimate the decision level critical value (LoB) using parametric and non-parametric estimator on blank material or via the precision profile variance function.
- Estimate the detection limit (LoD) using non-blank material or via the precision profile variance function.
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Version 3.90
(23 Feb 2015)
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Correlation / PCA / EFA - Added Exploratory Factor Analysis (EFA)
Fixed recalculate active analysis after changing filter Improvements for installation in virtualised environments Added floating-user licence monitoring in the About Analyse-it dialog box |
2014 |
Version 3.80
(15 Aug 2014)
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Correlation / PCA - Added Principal Component analysis (PCA)
- Added biplot - PCA/correlation/covariance
- Added color maps on correlation and other patterned matrices
- Added PCA tutorial with video
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Version 3.76
(8 Jul 2014)
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Method Comparison - Added non-parametric Bland-Altman limits of agreement tutorial
Distribution - Added option for 1st and 99th percentile
Support for dates in categorical data |
Version 3.75
(24 Apr 2014)
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Method Comparison - Added Bland-Altman limits of agreement based on ratio of measurements, linear regression, and non-parametric percentile method.
- Added in-depth tutorial on how to establish limits of agreement in various different situations.
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Version 3.71
(23 Apr 2014)
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Method Comparison |
Version 3.70
(24 Mar 2014)
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Compare groups - Added multiple comparisons: Hsu with Best, Scheffe, Steel (non-parametric against control), Dwass-Steel-Critchlow-Fligner (non-parametric all pairs), Wilcoxon (individual comparisons).
- Added p-value on all multiple comparisons.
- Added graphical confidence intervals on Excel 2010 and later.
- Added mean-mean scatter plot for representing multiple comparisons.
Fit Model - Added lack of fit test for all simple regression models: Line, Polynomial, Logarithmic, Exponential, Power.
- Added maximum attainable R2 in conjunction with lack of fit test.
- Added save variables back to the dataset: Fitted Y, Residuals, Standardized Residuals, Studentized Residuals, Leverage, Cook's Influence.
- Added t-test on regression coefficients.
- Added standardized beta coefficients.
Correlation - Added covariance matrix
- Added correlation coefficient confidence intervals shown graphically on Excel 2010 and later.
Improved administrator help Minor fixes and improvements. |
2013 |
Version 3.60
(12 Dec 2013)
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Compare pairs - Added repeat-measures ANOVA
- Added Friedman test
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Version 3.53
(28 Nov 2013)
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Minor change to floating-user licences for use on virtual desktops. Minor bug fixes for Excel 2013. Bug fix for co-existence with Analyse-it v2.xx Bug fix for excessive CPU use before concurrent-user licence is acquired |
Version 3.52
(2 Oct 2013)
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Major new release of the Analyse-it Method Validation edition. Method Comparison - Method comparison functions: scatters plots, difference plots, and fits, are now in one place so it’s easy to make decisions or choose fits after looking at the data.
- Ordinary linear, Weighted linear, Ordinary Deming, Weighted Deming and Passing & Bablok regressions.
- Constant difference and relative difference plots with mean difference, allowable difference, and limits of agreement.
- Bootstrap confidence intervals for parameters and bias in Passing & Bablok regression.
- Exact p-values on CUSUM linearity test.
- Predict mean difference at decision levels.
- Equality and equivalence hypothesis tests at decision levels.
- Kappa and Weighted Kappa qualitative method comparison.
Precision - Graybill-Wang / Ting-Burdick-Graybill-Jeyaratnam-Lu modified large sample confidence interval estimators for variance components – produces confidence closer to the stated level than Satterthwaite confidence intervals, which can be too liberal.
- Support for unbalanced 1- and 2-factor nested random ANOVA models, for looking at precision between days, runs, laboratories, etc.
Linearity - Hsieh-Liu confidence interval estimator for degree of nonlinearity.
- Equality and equivalence hypothesis tests for nonlinearity.
Reference interval - Harrell-Davis, Bootstrap, and Robust Bi-weight quantiles.
- Box-Cox and other transformations.
Diagnostic performance / ROC - Compare up to 10 independent or correlated ROC curves.
- Equality, equivalence and non-inferiority hypothesis tests.
- Estimate false positive fraction (FPF) at fixed sensitivity, sensitivity at fixed FPF, and sensitivity/FPF at fixed cut-off.
- Find optimal decision threshold based on costs.
Binary diagnostic tests - Compare sensitivity and specificity of 2 independent or correlated tests.
- Diagnostic odds-ratio and Youden’s index.
- Improved confidence interval estimators for likelihood ratio and predictive values.
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Version 3.20
(28 Jun 2013)
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Distribution, Compare groups & pairs - Added assign Color / Symbol to categorical scale variables
- Added vary scatter and dot plot marker color / symbol by the categories of a variable
- Added vary frequency plot and mosaic plot color by categories of the variable
- Added quickly edit Sort order and Color / Symbol using variable options button on analysis task pane
Minor bug fix to the plot for non-English Excel users Minor bug fix for crash on start-up |
Version 3.15
(27 Feb 2013)
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Changed analysis commands to always show pop-up menu for access to starting points. |
Version 3.10
(25 Feb 2013)
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Added Statistical Reference guide to the help |
2012 |
Version 3.03
(20 Dec 2012)
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Minor change to avoid buffer overrun warning with Sophos anti-virus. |
Version 3.02
(24 Jul 2012)
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Major new release of the Analyse-it Standard edition. - Supports Excel 2007, 2010, & 2013, 32-bit and 64-bit versions
- Improved user interface for faster interactive analysis
Distribution - Histogram, polygon, cumulative histogram
- Univariate box-whisker, dot-, and mean-plots
- Distribution plots normal Q-Q, CDF plot
- Shapiro Wilk, Kolmogorov Smirnov, Anderson Darling normality tests
- Z-test, t-test, Wilcoxon, Sign
- Binomial test, Pearson X², Likelihood ratio G²
- Frequency plot, whole-to-part plots
Compare groups - Univariate box-whisker, dot-, and mean-plots
- Z-test, t-test, Welch t-test
- Wilcoxon Mann-Whitney test, Kruskal-Wallis test
- ANOVA, Welch ANOVA, Multiple comparisons
- Fisher F-test, Bartlett, Levene, Brown-Forsythe test for homogeneity
- Fisher exact, Pearson X², Likelihood ratio G²
- Mosaic plot
Compare pairs - Univariate box-whisker, dot-, and mean-plots
- Difference plot, histogram of differences
- Z-test, t-test
- Wilcoxon test, Sign test
- Frequency plot
Correlation - Scatter plot with density ellipse
- Scatter plot matrix with density ellipse and histograms
- Pearson, Spearman and Kendal correlation coefficient
Fit Model - Linear and logistic regression
- Simple models: linear, logarithmic, exponential, power, polynomial
- Advanced models with simple, crossed, polynomial, factorial terms, with categorical variables coded as dummy variables
- Leverage, residual, outlier & influence diagnostic plots
- Standardized & studentized residuals, Cook's D
- Test effect of each term, test effect of model
- Predict Y for X
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Version 2.30
(27 Oct 2012)
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Minor update, no bug fixes. |
Version 2.27
(15 Aug 2012)
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Minor fix for blank legend names on latest Excel 2007/2010 service packs |
2011 |
Version 2.26
(17 Oct 2011)
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Minor update to fix an issue on start-up with Excel 2010 with Service Pack 1 and the Office File Validation add-in. |
Version 2.25
(26 Aug 2011)
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Fixed CUSUM linearity test on Passing-Bablok |
Version 2.24
(10 May 2011)
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Fixed significance test on lack of fit for non-linear model on Linearity |
2010 |
Version 2.22
(6 Jan 2010)
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Compatible with Excel 2010 (32-bit only) - Added output of fit equation to linear & polynomial regression output
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2009 |
Version 2.21
(5 Aug 2009)
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Fixed occasional random crashes for users of Excel 2007. |
Version 2.20
(8 May 2009)
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- Added support for Excel 2007 expanded worksheet size: 1,048,576 rows and 16,384 columns.
- Fixed crash on Refresh/Collate caused by bug in Excel 2007 Service Pack 2.
- Fixed issue on Refresh/Collate when the workbook/worksheet containing the dataset had an apostrophe in the book/sheet name.
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Version 2.14
(30 Jan 2009)
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- Fixed percent style re-definition warning that sometimes appeared on report output.
- Fixed box-plots drawing where connecting lines sometimes appeared.
- Change to rounding of degrees of freedom in CLSI precision.
- Added option to suffix name of diagnostic test with /H or /L to force ROC algorithm to treat higher/lower values as abnormal.
- Added UpdateReport function to allow updating an Analyse-it report from VBA.
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2008 |
Version 2.12
(10 Oct 2008)
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- Fixed issue with significant figures formatting on the regression equation (on the scatter plot) for very large coefficients.
- Fixed Kruskal-Wallis contrasts p-value to a maximum of 1 (Bonferroni method can, in rare cases,calculate p-values larger than 1).
- Fixed cosmetic issue, due to a bug in Excel 2007 charts, where the horizontal X axis appeared sloped.
- Update network license no longer requires re-activation
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Version 2.11
(13 Jun 2008)
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- Added check to ensure all observations for Weighted Deming regression are greater-than zero.
- Changed ROC AUC confidence interval to be bounded between 0..1. No changes made to the AUC confidence interval calculation.
- Fixed label on regression output that shows the confidence level %, which always showed as 95% even if a different level was requested. The confidence intervals calculated are correct, and no changes made to the calculations.
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Version 2.10
(20 May 2008)
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- Fixed issue with CV on Weighted Deming Regression, where Analyse-it expected CV as a proportion rather than percentage when one methods CV was specified and other calculated from replicates.
- Fixed issue with Mark Outlier tool on non-English regional settings where comma was used as a thousand separator.
- Added Help button to test dialog box to open help for the test.
- Added index to Help.
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Version 2.09
(27 Mar 2008)
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- Fixed code-signing certificate expiry issue.
- Statistics in chart legends are now formatted to same precision as the source variables.
- Fixed display issue, where an advisory label indicating when methods compared using Passing-Bablok have a non-linear relationship (p-value > 0.10) was not shown.
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Version 2.08
(27 Feb 2008)
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- Fixed labelling of > and >= cut-off operators were reversed, performing >= and > respectively, on the Qualitative Test Performance in Method Evaluation edition.
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Version 2.07
(21 Jan 2008)
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- Fixed regression residual histogram scaling issue on Microsoft Excel 97-2003.
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Version 2.06
(10 Jan 2008)
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- Fixed chart axis label positioning issue that appeared on some non-English language versions of Microsoft Excel.
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2007 |
Version 2.05
(21 Dec 2007)
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- Kolmogorov-Smirnov now uses the method of Dallal & Wilkinson (The American Statistician, 1986, Vol 40, No 4, pg 294-296) for computation of p-values. The new method is more accurate for small sample sizes.
- Kolmogrov-Smirnov and Anderson-Darling now report the D and A2 statistic directly rather than the sample stabilized A* and D*.
- Added 1st and 3rd Quartile to comparative descriptives output.
- Added TP / TN / FP / FN to ROC curve output.
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Version 2.04
(12 Oct 2007)
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Added Getting Started tutorial. |
Version 2.03
(15 May 2007)
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True Excel 2007 interface, with quick access to tests and tools. - Simpler dataset setup with predefined experiment templates.
- Improved histograms, box-plots, mean-, dot- and scatter plots.
- Major improvements to all the statistical tests, especially the Method Evaluation edition.
- New easy-to-read online help, with a new Getting Started tutorials.
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2006 |
Version 1.73
(13 Mar 2006)
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Existing users are encouraged to update to v2. |
2004 |
Version 1.72
(5 Jan 2004)
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Made Kappa test available to the General statistics module. Added an option to omit confidence intervals on comparative box-plots, useful when the sample size is small and box plots appear 'inside-out'. |
2002 |
Version 1.64
(19 Sep 2002)
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Changed Passing-Bablok method conversion (regression) algorithm to handle ties in Y. |
Version 1.63
(11 Jul 2002)
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Modified plotting of ROC curves slightly so the end of the curve is always joined to (1,1) |
Version 1.62
(31 May 2002)
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Office XP compatible Improved license system and installer. Existing users upgrading to version 1.60 or later must request a license key (see below). Added linearity protocol. No documentation is included for this procedure as yet, but an example called "Linearity.xls" is included in the "Analyse-it\System\Examples" folder. If you have any questions please contact us. Changed linear regression prediction intervals to use t-distribution instead of F-distribution. Warning: the new t-distribution implementation yields narrower prediction intervals compared with the F-distribution. Added "no intercept in model" to linear regression allowing fitted regression line to be forced through 0 (a.k.a. zero forcing). Corrected problem where confidence level was not shown on linear regression. Confidence intervals were correct, but confidence level was always shown as 95% instead of chosen level. Fixed bug in 2-run precision analysis when comparing within-run observed precision against precision claim. |
1999 |
Version 1.42
(22 Mar 1999)
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Modified Deming regression residual plot to use standardized residuals instead of absolute residuals to allow easier spotting of outliers (use standard +/- 4 SD rule). Added 'Linear method comparison' procedure -- basically linear regression modified to be better suited for method comparison studies (p-value tests slope against a hypothesis of 1). Fixed bug in non-parametric reference intervals, where upper confidence level was reported even though too few samples (less than 119 samples). |
Version 1.40
(1 Feb 1999)
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Made Analyse-it Office/Excel 2000 compliant. Also fixed new problems introduced by Microsoft Office/Excel 97 service packs. |
Version 1.37
(18 Jan 1999)
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Improved ROC analysis, with tables showing sensitivity/ specificity/predictive-values for all possible decision-thresholds of each diagnostic test. |
1998 |
Version 1.31
(1 Sep 1998)
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Improved linear regression algorithm to produce more accurate results when dependant variables are highly co-linear (now results are more accurate than Minitab!) |
Version 1.28
(27 Apr 1998)
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Modified precision plot, and fixed bug in the %difference plot of bias plots. Modified ROC analysis to automatically decide whether higher or lower diagnostic results indicate normal or abnormal. |
Version 1.25
(22 Feb 1998)
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Added residual plots to Deming and Passing-Bablok method comparison procedures. |