Release version 4.00.1

Released 7-Jul-2015
Version 4.00.1
Dual 32/64-bit installer (13.19 MB)
System requirements
  • Excel 2007, 2010, 2013 (32 & 64-bit)
  • Windows Vista, 7, 8, 10, 11, & Server 2003, 2008, 2012, 2016

Alternative download formats
.ZIP .MSI for Excel 32-bit .MSI for Excel 64-bit

 Installation instructions
 Concurrent-user installation instructions

Changes, bug fixes & improvements in this release:

Analyse-it Method Validation edition, version 4.00

  • Support for CLSI guidelines

Reference interval

  • Partition factors for separate reference interval analysis of sub-groups.
  • Additional transformation functions: Manly exponential, 2-stage Exponential/Modulus transformation.
  • Normal MVUE quantile estimator for reference limits.

Diagnostic performance

  • Bi-Histogram and dot-pot of the distribution of positive/negative cases.

Method comparison

  • Adjust measuring interval to a linear range and extrapolate fits beyond the data to the measuring interval.
  • Partition into measuring intervals, with different relationships (e.g. constant / relative differences or variances) for each measuring interval.


  • Improved report and plots.
  • Integrated into MSA to allow unified approach to evaluation of other components of error.


  • Improved report and plots.
  • Precision profile variance function fits with a choice of 7 fits, including Sadler 3-parameter functions.
  • Limit of quantitation via prediction from CV% on precision profile plot.

Trueness (NEW!)

  • Estimate bias with reference materials or PT/EQA material.

Detection capability (NEW!)

  • Estimate the decision level critical value (LoB) using parametric and non-parametric estimator on blank material or via the precision profile variance function.
  • Estimate the detection limit (LoD) using non-blank material or via the precision profile variance function.

See full release history

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