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Normal theory quantile

A quantile estimator derived from a normally distributed population with unknown mean and standard deviation.

A normal theory quantile is most powerful when a random sample is from a population with a normal distribution.

Estimator Description
MVUE The uniformly minimum unbiased variance quantile estimator uses the sample mean and unbiased standard deviation as the best estimate of the population parameters (Xbar ± Z(alpha) * (s / c4(n))). The factor c4(n) is applied to the sample standard deviation to account for the bias in the estimate for small sample sizes.
t-based The t-based prediction interval quantile estimator uses the Student's t distribution for a prediction interval (Xbar ± t(alpha, n-1) * s * sqrt(1+1/n)) for a single future observation (Horn, 2005). Note that this method produces a wider interval than the MVUE estimator for small samples.

In many cases, the data are skewed to the right and do not follow a normal distribution. A Box-Cox (or logarithmic) transform can correct the skewness, allowing you to use the Normal theory quantile. If not, a distribution-free estimator may be more powerful (IFCC, 1987).

Related information
Horn, P. S., & Pesce, A. J. (2005). Reference intervals: a user's guide. American Association for Clinical Chemistry.
Solberg, H. E. (1987). Approved recommendation on the theory of reference values. Part 5. Statistical treatment of collected reference values. Determination of reference limits. Clinica Chimica Acta, 170(2), S13-S32.
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Version 6.15
Published 18-Apr-2023
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