Statistics add-in software for statistical analysis in Excel
  • Statistical Reference Guide
  • Measurement systems analysis (MSA)
  • Detection capability

Limit of detection (LoD)

Limit of detection (also known as the minimum detectable value) is the quantity value, for which the probability of falsely claiming the absence of a measurand in a material is beta, given probability (alpha) of falsely claiming its presence.



Related concepts
Limit of blank (LoB)
Related tasks
Estimating the detection limit of a measurement system
Estimating the detection limit using a precision profile
Estimating the detection limit using a probit fit
Related information
Linnet, K., & Kondratovich, M. (2004). Partly nonparametric approach for determining the limit of detection. Clinical chemistry, 50(4), 732-740.
Currie, L. A. (1999). Detection and quantification limits: origins and historical overview. Analytica Chimica Acta, 391(2), 127-134.
Sadler, W. A., (2016). Using the variance function to estimate limit of blank, limit of detection and their confidence intervals. Ann Clin Biochem, 53, 141-149.
Available in Analyse-it Editions
Method Validation edition
Ultimate edition

  •  What is Analyse-it?
  •  What's new?
  •  Administrator's Guide
  •  User's Guide
  •  Statistical Reference Guide
  •  Distribution
  •  Compare groups
  •  Compare pairs
  •  Contingency tables
  •  Correlation and association
  •  Principal component analysis (PCA)
  •  Factor analysis (FA)
  •  Item reliability
  •  Fit model
  •  Method comparison / Agreement
  •  Measurement systems analysis (MSA)
  •  Precision
  •  Trueness
  •  Detection capability
  •  Limit of blank (LoB)
  •  Limit of detection (LoD)
  •  Estimating the detection limit of a measurement system
  •  Estimating the detection limit using a precision profile
  •  Estimating the detection limit using a probit fit
  •  Limit of quantitation (LoQ)
  •  Study design
  •  Reference interval
  •  Diagnostic performance
  •  Survival/Reliability
  •  Control charts
  •  Process capability
  •  Pareto analysis
  •  Study Designs
  •  Bibliography



Version 6.15
Published 18-Apr-2023
statistics software, statistical software for Excel
  • Products
  • Store 
  • Support
  • Blog
  • About us
  • Download trial
  •  Search
  •  Sign in
  •  Contact us
Analyse-it editions
  • Standard edition
  • Medical edition
  • Method Validation edition
  • Quality Control & Improvement edition
  • Ultimate edition

  • Blog  
  • About us
  • Contact us  
  • Privacy policy


Copyright 2026 Analyse-it Software, Ltd, Leeds, United Kingdom .
We use essential cookies to run the site, and optional analytics to improve the experience for visitors. For more information see our Privacy policy.