There is no set procedure to determine the limit of quantitation. Some authors suggest setting separate goals for bias and imprecision. Others such as Westgard use a model to combine the bias and imprecision into "total error" and compare it to a total allowable error goal. Others prefer to avoid the use of models and estimate total error directly using difference between the results of a method and a reference method (Krouwer, 2002). In other areas such as immunoassays the limit of quantitation is often defined as functional sensitivity where the precision profile function CV is equal 20%.
From the Statistical Reference Guide for Analyse-it 6.24.0: https://analyse-it.com/docs/user-guide/measurement-systems-analysis/detection-capability/loq
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