Testing the difference between the areas under two curves

Test if the area under curves is equal, equivalent, or not inferior to another.

1. Activate the analysis report worksheet.
2. On the Analyse-it ribbon tab, in the Diagnostic Accuracy group, click Test, and then click:

   Option	Description
   Equality	Test if the AUCs are equal.
   Equivalence	Test if the AUCs are equivalent within a practical difference.
   Non-inferiority	Test if the AUC is not inferior to another AUC.

   The analysis task pane Comparisons panel opens.
3. In the analysis task pane, under the hypotheses drop-down list:
   • If testing a hypothesis of equivalence, in the Contrast drop-down list, select the comparisons, and then in the Equivalent difference, type the smallest practical difference that would be considered the same.
   • If testing a hypothesis of non-inferiority, in the Standard drop-down list, select the standard diagnostic test, and then in the Smallest difference edit box, type the smallest difference that would be considered inferior.
4. Optional: To compare the p-value against a predefined significance level, in the Significance level edit box, type the maximum probability of rejecting the null hypothesis when in fact it is true (typically 5% or 1%).
5. Click Recalculate.