Mean difference measures the constant relationship between the variables. An assumption is that the difference is not relative to magnitude across the measuring interval. If the differences are related to the magnitude, the relationship should be modeled by using relative differences or regressing the differences on the true value.
From the Statistical Reference Guide for Analyse-it 6.24.0: https://analyse-it.com/docs/user-guide/method-comparison/d-on-a-fit
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