Study design
Method comparison study requirements and dataset layout.
Requirements
- 2 quantitative variables.
- A recommended minimum of at least 40 cases.
- Each measurement in singlicate or replicate.
Paired dataset layout
Use a column for each method (Method 1, Method 2); each row has the measurement by each method for an item (Subject).
| Subject (optional) | Method 1 | Method 2 |
|---|---|---|
| 1 | 120 | 121 |
| 2 | 113 | 118 |
| 3 | 167 | 150 |
| 4 | 185 | 181 |
| 5 | 122 | 122 |
| … | … | … |
Paired dataset layout with replicates
Use multiple columns for the replicates of each method (Method 1, Method 2); each row has the replicate measurements by each method for an item (Subject).
| Subject (optional) | Method 1 | Method 2 | ||
|---|---|---|---|---|
| 1 | 120 | 122 | 121 | 120 |
| 2 | 113 | 110 | 118 | 119 |
| 3 | 167 | 170 | 150 | 155 |
| 4 | 185 | 188 | 181 | 180 |
| 5 | 122 | 123 | 122 | 130 |
| … | … | … | … | … |
Paired dataset layout with matched replicates
Use a column for each method (Method 1, Method 2); each row has the measurements by each methods for an item (Subject), with multiple rows for replicates of each item.
| Subject | Method 1 | Method 2 |
|---|---|---|
| 1 | 120 | 121 |
| 1 | 122 | 120 |
| 2 | 113 | 118 |
| 2 | 110 | 119 |
| 3 | 167 | 150 |
| 3 | 170 | 155 |
| 4 | 185 | 181 |
| 4 | 188 | 180 |
| 5 | 122 | 122 |
| 5 | 123 | 130 |
| … | … | … |
Matched dataset layout
Use a column for the measurement variable (Measured value), a column for the method variable (Method), and a column for the item variable (Subject); each row has the measurement for a method for an item (Subject), with multiple rows for replicates of each item.
| Subject | Method | Measured value |
|---|---|---|
| 1 | X | 120 |
| 1 | X | 122 |
| 1 | Y | 121 |
| 1 | Y | 120 |
| 2 | X | 113 |
| 2 | X | 110 |
| 2 | Y | 118 |
| 2 | Y | 119 |
| 3 | X | 167 |
| 3 | X | 170 |
| 3 | Y | 150 |
| 3 | Y | 155 |
| 4 | X | 185 |
| 4 | X | 188 |
| 4 | Y | 181 |
| 4 | Y | 180 |
| 5 | X | 122 |
| 5 | X | 123 |
| 5 | Y | 122 |
| 5 | Y | 130 |
| … | … | … |